Major breakthrough in oral cancer cure

BM, 09-10-2011 19:50:37

Write Comment     |     E-Mail To a Friend     |     Facebook     |     Twitter     |     Print

Genome sequencing by a Bangalore lab will help early detection and in patient-specific treatment options

Genome sequencing is not just a fad in Bangalore’s biotech industry. It is all set to achieve a major breakthrough in the treatment of oral cancer. Bangalore-based Ganit Labs has made steady progress in sequencing genomes of oral cancer patients. This will facilitate early detection and even help doctors suggest tailor-made treatment options.

Dr Binay Panda, head of Ganit Labs, said, “As far as incidence and mortality rate of oral cancer goes, India is ahead of Japan and US. Nearly 25-30 per cent of the total cancer patients among males in India are affected by head and neck cancer.”

Oral cancer is categorised by the lab, located in the Institute of Bioinformatics and Applied Biotechnology (IBAB) Centre in Electronics City, under head-and-neck cancer.

Currently, the identification of oral cancer is largely done on the basis of checking the medical history of patients, physical examination of the oral cavity and through pathological tests. “Sometimes a cell might not appear abnormal under a microscope but might harbour genetic changes that could lead to it turning into a tumour cell. If we know what and where to look at, one could do focused experiments but unfortunately we don’t. Hence, unbiased sequencing of the cancer genome would get us to the root and might help in identifying the potential reason behind the disease,” Dr Panda said.

The oral cancer study is being done in collaboration with Mazumdar Shaw Cancer Centre of Narayana Hrudayalaya. Dr Panda said, “Genome is the collection of genes and other non-coding parts that is made up of individual nucleotides A, T, G and C arranged in different combinations. If you compare the genomes of different samples of cancer patients with those of normal individuals, the pattern in which A, T, G and C are arranged is different. Once we know where the changes are, we correlate that with the disease. Once samples are collected, they are processed in the laboratory to extract DNA, which is sequenced.”

The team at Ganit Labs is mainly sequencing the genomes in the backdrop of a person’s changing habits. “You cannot stop cancer if you are inheriting the changes. But if the disease is linked to a particular habit, we need to know what are those exact changes in the genomes to which a particular habit is linked with,” says Dr Panda. This apart, the sequencing may also reveal the effect of a particular drug on patients. “If you are administering the same drug to two patients, one might respond well while another might not. Sequencing might shed light on which genetic changes are responsible for the action of a particular drug. Out of the samples we have sequenced, we have identified specific genetic signatures that we are analysing,” Dr Panda said.

“Though the biotech industry in the state is vibrant, the lack of equipment and skilled researchers have retarded progress. We rely upon equipment from the West for our studies. Some equipment require huge investments running into several crores of rupees. The problem is that development of these equipment requires multi-discipline knowledge, which we lack here. If any Indian firm takes up manufacturing these sequencing equipment, they may become affordable and eventually prompt many more to take up projects in the subject,” explained  another researcher.

Further, the falling number of researchers has also crippled the process of research. “Sequencing is not just about bioscience but incorporates several other fields such as computers and biochemistry. A computer engineer need not back off saying it is just bioscience domain as he too has a role to play in sequencing experiments. But unlike other fields, results in biotechnology are very slow. One needs to be patient,” explained Dr Panda. Currently, his team is working with more than 10 researchers.

Recently, the lab had sequenced the genome of the neem plant for the first time in the world. Another team at the Institute is trying sequence genomes of the local variant of Amaranth leaves (harive soppu). Prof N Yathindra, director of IBAB Centre, told Bangalore Mirror, “The plant is rich in lysine, a type of essential amino acid. The human body can synthesise a few forms of amino acids but not essential ones. They need to be supplied through our food. Lysine is one such amino acid. It helps digestion and metabolism. We are trying to sequence the genome of this plant for better utilisation of this amino acid.”

The institute also has plans of taking up studies into male infertility.

Write your Comments on this Article
Your Name
Native Place / Place of Residence
Your E-mail
Your Comment   You have characters left.
Security Validation
Enter the characters in the image above
Disclaimer: Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. will not be responsible for any defamatory message posted under this article.
Please note that under 66A of the IT Act, sending offensive or menacing messages through electronic communication service and sending false messages to cheat, mislead or deceive people or to cause annoyance to them is punishable. It is obligatory on to provide the IP address and other details of senders of such comments, to the authority concerned upon request. Hence, sending offensive comments using will be purely at your own risk, and in no way will be held responsible.
Similarly, reserves the right to edit / block / delete the messages without notice any content received from readers.

Watch Full Video:Inauguration Udupi of Diocese
View More

Mount Rosary Church Annoucement for the weekMount Rosary Church Annoucement for the week
Rozaricho Gaanch Easter 2018Rozaricho Gaanch Easter 2018
Milarchi Lara - Issue April - 2018Milarchi Lara - Issue April - 2018
Delite Caterers and Delite Event ManagementDelite Caterers and Delite Event Management
An appeal to Kemmannu Parishioners, Friends and Well Wishers:


An appeal to Kemmannu Parishioners, Friends and Well Wishers:<P> <Center>[Comments]</P> </Center>
Milarchi Laram - Issue Jan 2018Milarchi Laram - Issue Jan 2018
Read online Uzvaad:<font color=red> Read online Uzvaad</font color=red>:
Visit Axis Bank Now open in Kallianpura, SanthekatteVisit Axis Bank Now open in Kallianpura, Santhekatte
For all your travel needs contact Sequeira TouristFor all your travel needs contact Sequeira Tourist
Power Care Services, MoodubellePower Care Services, Moodubelle
Read Online RaknnoRead Online Raknno
Kemmannu Platinum Jubilee Souvenir – Amruth KaanikKemmannu Platinum Jubilee Souvenir – Amruth Kaanik
Udupi TodayUdupi Today
St. Alphonsa of India
Mangalorean Fertility Physician in New York


Mangalorean Fertility Physician in New York


For information, please email or contact Megi Zeku at 646-962-7499, prompt 3.



Thank you from Kemmannu.comContact for all your Travel, Tours and For Rent a Car

Contact Maria Travels  for all your Travel, Tours and For Rent a Car Mob: 9980889512 or 9819444307

Thanksgiving to St. Lawrance

Thanksgiving to St. Lawrance

Sponsored Albums